RAS-2410 hydrochloride
- Product Name
- RAS-2410 hydrochloride
- CAS No.
- 1187075-34-8
- Chemical Name
- RAS-2410 hydrochloride
- Synonyms
- Resminostat HCl;RAS2410 hydrochloride;4SC-201 hydrochloride;RAS-2410 hydrochloride;RAS 2410 hydrochloride;ResMinostat (hydrochloride);Resminostat hydrochloride (4SC-201);RAS2410; 4SC-201; RAS 2410; RAS-2410;4SC201;4SC 201;RAS2410 HYDROCHLORIDE; 4SC-201 HYDROCHLORIDE; RAS 2410 HYDROCHLORIDE; RAS-2410 HYDROCHLORIDE;(2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1)
- CBNumber
- CB92666678
- Molecular Formula
- C16H20ClN3O4S
- Formula Weight
- 385.8657
- MOL File
- 1187075-34-8.mol
RAS-2410 hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17553
- Product name
- Resminostat (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 17553
- Product name
- Resminostat (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- 17553
- Product name
- Resminostat (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $310
- Updated
- 2024/03/01
- Product number
- 17553
- Product name
- Resminostat (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $947
- Updated
- 2024/03/01
- Product number
- A3755
- Product name
- Resminostathydrochloride
- Packaging
- 50mg
- Price
- $1010
- Updated
- 2021/12/16
RAS-2410 hydrochloride Chemical Properties,Usage,Production
Description
Resminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells. It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 μM). Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209. It dose-dependently inhibits HDAC activity in vivo.
References
[1] mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010 may;149(4):518-28.
[2] brunetto at, ang je, lal r, olmos d, molife lr, kristeleit r, parker a, casamayor i, olaleye m, mais a, hauns b, strobel v, hentsch b, de bono js. first-in-human, pharmacokinetic and pharmacodynamic phase i study of resminostat, an oral histone deacetylase inhibitor, in patients with advanced solid tumors. clin cancer res. 2013 oct 1;19(19):5494-504.
RAS-2410 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
RAS-2410 hydrochloride Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
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- 4662
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- 60
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58
View Lastest Price from RAS-2410 hydrochloride manufacturers
- Product
- RAS-2410 hydrochloride 1187075-34-8
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-18